Meal-stimulated gastric acid secretion and gastrin release in patients with gastric or duodenal ulcer - A study by intragastric titration method.:A Study by Intragastric Titration Method

概要

論文の詳細を見る
Gastric acid secretion stimulated by beef consomme soup was measured in 7 normal controls, 16 gastric ulcer patients and 19 duodenal ulcer patients by intragastric titration to a constant pH 5.5 and 2.5. Serum gastrin was also measured by radioimmunoassay, using Dinabot gastrin kit. The ratios of acid output and integrated gastrin response (IGR) at pH 2.5 vs pH 5.5 were calculated to determine the rate of suppression in acid and gastrin responses at low acid pH.In duodenal ulcer patients, acid response was decreased only by 35%, compared with 45% in normal controls and 48% in gastric ulcer patients. IGR was suppressed by 62% in normal controls and 63% in gastric ulcer patients, whereas the rate of suppression was only 16% in duodenal ulcer patients. These differences were statistically significant. The results suggest that a defect in negative feedback mechanism of gastric acid secretion and gastrin release atlow pH exists in duodenal ulcer patients.
財団法人日本消化器病学会の論文