:With special reference to γ-carboxyglutamic acid-containing protein

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In order to elucidate the mechanism of formation of calculi in the pancrearic duct which are often found in the course of chronic pancreatitis, human pancreatic calculi were analyzed biochemically with attention focused on the affinity of γ-carboxyglutamic acid-containing protein for calciumions. The following results were obtained.1. The main component of human pancreatic calculi was calcium carbonate.2. Human calculi contained about 5% organic compounds.3. Human pancreatic calculi contained a high concentration of protein (estimated molecular weight 14, 500) rich in acidic amino acids.4. The presence of γ-carboxyglutamic acid as a constituent amino acid of this protein was confirmed.Since γ-carboxyglutamic acid-containing protein had a specific affinity for calcium ions, γ-carboxyglutamic containing protein with an estimated molecular weight of 14, 500 was assumed to play an important role in the formation of pancreatic calculi composed mainly of calcium.
財団法人日本消化器病学会の論文