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Effect of anti-ulcer drugs on the hemodynamics and oxygen sufficiency in the gastric mucosa of rats was studied by a reflectance spectrophotometry. Histamine H2 receptor antagonists (cimetidine, ranitidine), muscarin receptor antagonist (pirenzepine) and prostagladin E1 derivative (17S-20-dimethyl-6-oxo-prostaglandin E1 methyl ester) were administered, and the mucosal blood volume and oxygen saturation of hemoglobin in the gastric mucosa were examined for 30min. Thereafter, 2% blood of body weight was removed from a carotid artery in 15min, and, again, the gastric mucosal blood volume and oxygen saturation of hemoglobin were estimated from the spectra which were taken at every 5min for 30min after hemorrhgae.At basal state before hemorrhage, all anti-ulcer drugs did not effect the gastric hemodynamics and oxygen sufficiency.In face of hemorrhagic shock, all drugs inhibited the decreases of mucosal blood volume and oxygen saturation of hemoglobin in the gastric mucosa and also protected the formation of stress ulceration.In conclusion, these results suggest that histamine H2 receptor antagonists, muscarin receptor antagonist and prostaglandin E1 derivative had the protective effect against the decresaes of mucosal blood volume and hypoxia in face of hemorrhagic shock, thus preventing the gastric mucosa from ulceration.
財団法人日本消化器病学会の論文