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Serum sialic acid levels were determined in acute and chronic hepatitis (13 and 20 cases respectively), fatty liver (19 cases), compensated and decompensated cirrhosis (52 and 22 cases respectively), hepatoma (20 cases) and metastatic liver cancer (20 cases). The level in compensated cirrhosis was significantly lower than in control normal subjects (1.18±0.18 mM vs. 1.51±0.12 respectively, p<0.001), and it was further reduced in decompensated ones, whereas the levels in acute and chronic hepatitis and fatty liver appeared to be similar to control. The level in hepatoma was found to be elevated in spite of the association of advanced cirrhosis with them except for two cases (1.82±0.57 in all and 1.70±0.44 in cases with cirrhosis). This level was significantly higher than the levels in cirrhosis (p<0.01). In 60% of the cases with metastatic liver cancer, the level was much higher than the upper range of the normal, and the average was significantly higher than control (2.25±0.64, p<0.001).The mean of sialic acid content in hepatoma tissues studied in three cases was 40μg per mg protein of crude preparation of hepatocyte membrane, that was greater than in noncancerous part of the liver (14μg per mg protein). The result indicated the related increase of sialic acid in serum and the tissue at least in hepatoma.The measurement of serum sialic acid can be clinically useful for the diagnosis of cirrhosis and liver cancers.
- 財団法人 日本消化器病学会の論文
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