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• The etiology of stress ulcer has been extensively discussed. However, the pathogenesis of stress ulcer was still unresolved. In the present studies, author have attempted to evaluate the roles of catecholamines and sympathetic nervous system in restraint and water immersion stress in rats.Method: The area of ulcer was expressed by ulcer index and catecholamine contents in the brain and adrenal gland were analysed biochemically.Results: Administration of epinephrine and phenylephrine as α-stimulant, showed significantly decrease on the ulcer index. Due to the treatment of surgical sympathectomy and adrenalectomy, the ulcer index was significantly increased. On the other hand, the relationship between ulcer index and brain catecholamine contents or adrenal catecholamine contents in the various time intervals revealed a reverse correlation. Due to the increment of brain catecholamine contents after dosing of MAO-I, ulcer index was decreased.Conclusion: From the results mentioned above, catecholamines and sympatheticadrenal axis was assumed to have an inhibitory effect on the stress ulcer formation.

• 財団法人 日本消化器病学会の論文

著者

• 金沢 寛

  順天堂大学第一外科

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