:Establishment of Assay Procedure and Effects of Nonsteroidal Antiinfiammatory Compounds

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The property of prostaglandins (PGs) protecting the gastrointestinal mucosa against various ulcerogens was called cytoprotection by Robert, and has been given marked attention. However, concerning endogenous PGs in the gastric mucosa, only a few reports were present. Recently, the authors established the method of the intramucosal PGE2 determination. Effects of indomethacin and mefenamic acid to PGE2 levels in the gastric mucosa were investigated in this paper.PGE2 levels in the antral mucosa were significantly high (3.95±0.55 tg/g w.w.) compared with the levels in the fundic mucosa (1.76±0.13). PG2 contents of both the fundic and the antral mucosa were markedly reduced on thirty minutes after the oral administration of indomethacin at a dose of 6 mg/kg (0.41±0.15 and 0.72±0.33, respectively). On the other hand, no significant change was detected after mefenamic acid administration (200 mg/kg per os). Intramucosal cyclic AMP contents were significantly reduced in the indomethacin group.In these results, it is suggested that differences between the fundic and the antral levels of intramucosal PG2 may be correlated with location of the mucosal damage. It is also suggested that the degree of intramucosal PG2 inhibition may be different between the two non-steroidal antiinflammatory compounds. Further, it is more likely that intramucosal PGs may act through cyclic AMP system.
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