Studies on metabolic abnormalities of the rat liver in fatty liver cirrhosis induced by chnline-deficient diet:Part I. The respiratory control index and oxidative phosphorylation of isolated liver mitochondria

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The respiratory control index and oxidative phosphorylation of the isolated rat liver mitochondria were measured by an oximeter to examine the metabolic abnormalities of the liver during the development of hypertrophic nodular liver cirrhosis from the hypertrophic fatty liver. The results were as follows:1. The impairment of oxidative phosphorylation of the isolated liver mitochondria was first observed at 3 to 4 weeks after the rats were placed on the diet. The histological investigation indicated a hypertrophic fatty liver.2. Marked impairment of mitochondrial function such as reduced respiratory control index and decreased oxidative phosphorylation, was observed in rats with hypertrophic nodular cirrhosis.3. The metabolic abnormalities induced by the hypertrophic nodular cirrhosis from the hypertrophic fatty liver were shown to arise in the energy synthesis system of mitochondria. The abnormalities were accentuated to a nodular fatty liver when the rats were placed on the choline-deficient for more than 6 months.4. The isolated mitochondria of rats on the choline-deficient diet partially supplemented by sucrose with xylitol for 6 to 9 months showed nearly normal respiratory control indices and oxidative phosphorylation. The restoration of mitochondrial function is thought to be closely related to the inhibition of fat accumulation and subsequent cirrhosis.
財団法人日本消化器病学会の論文