Studies on Serum Protein Binding Form of Indocyanine Green

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Serum protein binding form of Indocyanine green (ICG) was examined by the following methods; starch block electrophoresis using the ICG labeled serum, immunoelectrophoresis and electrofocussing fractionations.Large peak of the ICG binding form in albumin fraction and small peak of the ICG binding form in β-globulin fraction were observed by starch block electrophoresis.These fractional extracts were subdivided by gel filtration in Sephadex G-200, and then were analyzed using immuno-electrophoresis. Major peak mainly consisted from α1-lipoprotein (a1-LP) and minor peak consisted from β-lipoprotein (β-Lp), also same results were obtained from the method of electrofocussing fractionations.From these results, ICG bound mainly to a1-Lp and β-Lp, but bound scarcely to albumin and might be have a poor affinity.
財団法人日本消化器病学会の論文