リン脂質およびその加水分解生成物の抗酸化作用 (第6報) : アミングループを有するリン酸エステルの抗酸作用機構とレシチンの抗酸化作用に関係する分子の配座構造

概要

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Phosphorylcholine (PC), phosphorylethanolamine (PE), glycerylphosphorylethanolamine (GPE) and glycerylphosphorylcholine (GPC) exhibited antioxidant activities in a concentration range from 0.01 to 0.04% in unsaturated fatty acid esters, and these compounds as well as β-glycerylphosphoric acid (β-GP) and tributyl phosphate (TBP) showed synergistic activities with hydroquinone. The infrared spectrum of methyl linoleate (MeL) containing 0.03 % of GPC showed the same characteristic absorption bands as those observed in the case of β-GP and TBP added to the same substrate. These results suggest that a mechanism for the antioxidant activity of GPC also involves an interaction of the PO group possibly with the α-methylene group of the MeL molecule. Accordingly, a mechanism for the synergism shown by GPC, β-GP and TBP with hydroquinone and that reported by Olcott for lecithins and inositol phosphatides with ethoxyquin may not conform with the general concept that phosphate esters act as hydroperoxide decomposer.