電位差滴定による低過酸化物価測定法 (第6報) : 各種疾病患者の血清過酸化脂質量

概要

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The lipid peroxide levels in sera of ca. 500 patients suffering from various diseases were determined by the potentiometric POV method. The average values of serum lipid peroxide levels in patients suffering from cerebrovascular disease, heart disease, hypertension, hepatic disease, cataract and glaucoma, bronchitis, ulcer and bronchial asthma were found to exceed those of the normal human group. In patients with cerebrovascular disease, hypertension and hepatic disease, the levels of serum lipid peroxides were particularly higher statistically than those of the normal human group with a 5% significance level. The large standard deviations in average peroxide levels of these groups were considered to arise from differences in age, sex, the particular diseases of the patient and his /her condition. The ratios of samples showing high levels of peroxide exceeding the normal range (40.9±22.8 neq/mL) were calculated for all the patients. The ratios of high level were observed in more than 30% of patients with cerebrovascular and hypertension, and in more than 20% with cancer and hepatic disease. Moreover, it was obvious that lipid peroxide levels in the sera of patients suffering from these 4 diseases rose more than in normal humans, although no correlation between lipid peroxide and lipid levels could be found.
社団法人日本油化学会の論文