リン酸化反応に関する研究 (第2報) : リン酸によるアルコールの直接リン酸化

概要

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To examine the mechanism of phosphorylation of alcohol (ROH) with phosphoric acid (PA), reaction of ROH with PA under azeotropical distillation was followed by measuring the amount of distilled water and 31P-NMR spectra of the reaction mixture. The results indicated that Direct-Phosphorylation of ROH with PA occurred. Under reduced pressure without a solvent, PA conversion increased linearly with time (h) in the range of about 20 to 50% conversion. The slop (k) was expressed by the equation (1) [ln k=r-10.6×103× (1/T) -7.85×10-4×P+28.05].Activation energy of the reaction was estimated as 21kcal/mol based on the above equation. Under dehydration conditions, the pyrolysis of MAP (Monoalkyl-phosphate) occurred spontaneously. Phosphorylation with highly concentrated phosphoric acid (polyphosphoric acid) at low temperature without dehydration was studied, and ROH was found to be converted almost quantitatively to MAP without pyrolysis.
社団法人日本油化学会の論文