自動酸化リノール酸メチルの投与における溶血とビタミンEとの関係
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概要
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Autoxidized oils including peroxide have been generally known to cause certain diseases in animals. It has been also known that the erythrocytes of vitamin E deficient animals easily hemolyze in the presence of hydrogen peroxide or dilauric acid <I>in vitro</I> due to the peroxidation of lipids in thier membranes. However, very few observations have been reported whether the erythrocytes of rats hemolyze or not when autoxidized oil is given orally.<BR>In the present paper, the authors examined the relation between the H<SUB>2</SUB>O<SUB>2</SUB>-induced hemolysis of the erythrocytes and the vitamin E contents of the sera of the rats fed on autoxidized methyl linoleate (AOML) or a mixture of AOML and vitamin E. The diet shown in Table-2 was given to rats in each experimental group for 7 days, respectively.<BR>The following results were obtained;<BR>1. The hemolysis of the erythrocytes in the rats fed on methyl linoleate appeared more frequently than in the rats fed on the basal diet.<BR>2. Higher hemolysis was observed in the erythrocytes of the rats fed on AOML than in those of the rats fed on methyl linoleate.<BR>3. Any hemolysis of the erythrocytes was hardly observed in the rats fed on the additional vitamin E with the basal diet containing methyl linoleate (fresh or autoxidized).<BR>4. The serum vitamin E content of the rat in the AOML group was the lowest of all the groups tested.<BR>From these results, the authors presumed that the hemolysis of the erythrocytes of the rats fed on AOML might be caused by the following process; Some digestible and absorbable components from AOML decreased <I>in vivo</I> serum vitamin E content below a level susceptable of vitamin E deficiency.
- 社団法人 日本油化学会の論文