アスベストのリンパ球系細胞機能に対する影響-2-石綿肺症におけるNK細胞活性,ADCC及びインタ-フェロンについて

概要

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There have been several reports of immunological abnormalities among asbestosis patients. The present study examines natural killer cell (NK cell) activity, antibody dependent cell-mediated citotoxicity (ADCC), interferon (IFN) and β2-microglobulin (β2-m), including IgA, IgG, IgM, IgE and blastoid transformation of lymphocyte responses to phytohemagglutinin (PHA) which are well recognized in asbestosis cases.Serum IgA, IgG, and IgE in asbestosis patients showed a significant increase in terms of the index of liquid immunology compared to normal subjects. However, serum IgM and lymphocyte transformation gave no significant differences for the two groups.It has been suggested that NK cell activity and ADCC may play an important role in imunosurveillance against tumors and viral infections. NK cell activity and ADCC in asbestosis patients were significantly lower than in the control group. As NK cell activity and ADCC may have similar cell structures, they were correlated. Here, a significant correlation was found for both groups.Serum IFNs in asbestosis patients had risen significantly over those of the controls, and it continued to increase. There was a significant inverse correlation between NK cell activity and serum IFN in asbestosis patients, but, there was not between ADCC and serum IFN in asbestosis patients.Surum β2-m was effective on the fibrosis index in asbestosis patients.
日本衛生学会の論文