血色素量と血球容積率の遺伝力
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概要
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A genetic analysis was made of the values of hemoglobin [Hb] and hematocrit [Ht] in family members. Hb and Ht were measured by the cyan-methemoglobin method and by the capillary tube method, in 650 men 1, 075 women, under the same ecological circumstances, aged from 20 to 64 years.Levels of Hb and Ht in men were always higher than those in women in all age groups. The Hb and Ht values decreased with increasing age in men. Changes in Hb and Ht values showed normal distributions, and were both regarded as quantitative characters influenced by the polygenic system.Correlations of Hb between father and son, mother and son and both parents and son were all statistically significant at the 5% level, but the correlation between father and mother was not significant. Correlations of Ht between father and son, mother and son, and both parents and son were significant except for that between father and son. The correlation of Ht between father and mother was insignificant. After correction of data by sex and age, the standard normal deviates (ZHb, ZHt) were determined. Correlations of corrected Hb and Ht values were then analysed. Correlations of ZHb between father and son, mother and son, and both parents and son were all significant. Correlations of ZHt between father and son, mother and son, and both parents and son were also significant except for the correlation between father and son. However, the correlations of ZHb and ZHt between father and mother were not significant. Correlations of Hb, ZHb, Ht and ZHt were all significant between midparent and son.Based on the above results, the genetic forces of hemoglobin and hematocrit were estimated from the one parent and son correlation and from the midparent and son regression. Heritabilities of Hb and Ht were from 0.518 to 0.704 and from 0.346 to 0.580, respectively.