糖尿病患者の Xanthurenic Acid 尿中排泄
スポンサーリンク
概要
- 論文の詳細を見る
Yahito Kotake1, 2) has shown that rats continuously fed a high fat and high protein diet contracted diabetes and excreted xanthurenic acid (XA). His coworker has taken urine samples from 23 human diabetics and concentrated them. After separating the urine components with solvent on paper chromatography, he identified XA with diazo, by Millons reaction and by the ferric sulfate test. XA was detected in most diabetic urine, but not in normal urine, which suggests that there is a significant relationship between XA and diabetes. But the existence of diabetics who do not excrete XA in their urine also has been noticed.Thus, we needed to clarify clinically the rate at which usual diabetic patients excrete XA. XA is known to be produced when there is a deficiency of vitamin B6. Therefore when patients excrete XA in their urine, the administration of vitamin B6 may have a therapeutic effect.In cases of mild or middle grade diabetics, only 30-50% of the patients excreted XA in their urine, but if they were loaded with tryptophan the ratio would increase. We believe that there are some diabetics whose tryptophan metabolism is distorted, since their excretion rate of XA in urine is much higher than that of healthy individuals. Whether these diabetic patients have a shortage of vitamin B6 or there is a decrease in the change of vitamin B6 to the active form, pyridoxal phosphate, is discussed.
- 日本衛生学会の論文
著者
関連論文
- 81)Carteololの日常生活時の期外収縮に対する効果について : 声音メモ付・携帯用テープ心電計を用いたpropranololに対する交叉二重盲検成績 : 日本循環器学会第49回近畿地方会
- 40) 遠心性左室肥大症例のT変化について : ベクトル心電図と心血管造影法との対比的研究 : 第39回日本循環器学会近畿地方会
- 脳血栓および心筋梗塞における線溶酵素療法の検討 : 第34回日本循環器学会近畿地方会
- 糖尿病患者の Xanthurenic Acid 尿中排泄
- タイトル無し