金属ヒュームの肺内沈着に関する研究 : 第3報 多分散不整形ヒュームのラット肺内への沈着率

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概要

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• Several kinds of polydispersed irregular metallic fumes, which were generated from antimony, cadmium and lead chloride by the high frequency electric furnace type fume generator, were inhaled by SPF male rats of Sprague-Dawley strain in a head-only exposure chamber for 90min in order to study the effect of particle size, biological activity and solubility of these fumes on the lung retention rate in rats.Results obtained from the inhalation experiment were as follows.1) Effect of particle size on the relative lung retention rate (RL) was the same as that obtained from the inhalation of monodispersed spheric metallic fume. Furthermore, the following relationship was found to exsit between RL and aerodynamic mass median diameter (AMD or Da): RL=K⋅Da-n.2) The index number of lung retention (n) of 1.34 in antimony fume was larger than that in lead or tellurium fume. This means that dependency on particle size was greatest in lung retention of antimony fume.3) RL of cadmium having irritant effect on lung was of about the same value as that of lead fume which was inert.4) RL of lead chloride which dissolve to an enormous volume in water was of the same value as that of lead fume which dose not dissolve in water.As a result of a series of metallic fume inhalation experiments, the author could recognize that the lung retention rate of metallic fume not only depended upon particle size but also influenced by the biological activity of each metallic fume.

• 日本衛生学会の論文

著者

• 本間 克典

  労働衛生研究所

関連論文

• 金属ヒュームの肺内沈着に関する研究 : 第3報 多分散不整形ヒュームのラット肺内への沈着率
• 金属ヒュームの肺内沈着に関する研究 : 第2報 単分散球形金属ヒュームのラット肺内への沈着率
• 金属ヒュームの肺内沈着に関する研究 : 第1報 ラット用金属ヒューム吸入実験装置

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