大気中金属の生体に及ぼす影響--大気中Cd,Pb,Fe,Mnのラット体内蓄積に関する研究
スポンサーリンク
概要
- 論文の詳細を見る
Among the air pollutants, oxides of sulfer and nitrogen as well as oxidant produce acute symptoms on the mucosa and others, while many of metal elements do not. But the latter, once introduced into the living body remain there longer than the former. The author has paid attention to a serious fact that air-polluting metal elements are unconsciously accumulated in the body to exert chronic effect, and so the animals bred in a general living environment to observe the effect of corpuscular substances which are contained in air pollution.As experimental animals, rats were used. They were bred at different places in Tokyo-in Ohta-Ku, where general metal pollution is at higher grade, and Koganei city where it is low, and the animal laboratory of this university as control. The breeding started at the age of 10 weeks under the same conditions but in different places. At 4, 8 and 12 months of breeding, metals (Cd, Pb, Fe, Mn) in the lungs, brain, liver, kindneys, blood and feces from the rats of the three places were assayed, and their lungs, livers, kidneys and spleens were microscopically observed, with the following results;1) The lung content of each metal was significantly higher in Ohta-Ku than in Koganei city at all of the 4, 8 and 12 months. As for the other organs, Cd content in the brain and kidney at 4 months, Pb in the brain at 4 months, in blood at 4 and 12 months, and in feces at 4 and 8 months, Fe in the liver at 4, 8 and 12 months, in blood at 8 and 12 months and feces at 4 months, and Mn in the liver at 12 months were significantly higher in the breeding place of Ohta-Ku than Koganei city.2) Gross observation of the lung on sacrifice revealed marked deposition of coal powder-like substance in the Ohta-Ku group, but not in the Koganei city group.3) Microscopically, phagocytes, ingesting dust were observed in the subpleura, pulmonary alveola, bronchus, perivascular region as well as in lymph nodes, lymph follicles and their surroundings.
- 日本衛生学会の論文