金属ヒュームの肺内沈着に関する研究 : 第1報 ラット用金属ヒューム吸入実験装置

スポンサーリンク

概要

• 論文の詳細を見る

• In the study of lung retention of metallic fume, it is necessary to generate monodispersed metallic fumes whose particle sizes are variable and to which experimental animals are exposed at constant concentration for a long period.<BR>However, an experiment of metallic fume inhalation is very difficult because there is no technique to generate metallic fumes having particle sizes as designed and to maintain a constant concentration. The author, therefore, designed and constructed a metallic fume inhalation apparatus, which consists of the monodispersed metallic fume generator and exposure chamber for rats which can be easily operated. To obtain a stable evaporation of metal in the generator, a high frequency electric furnace was used. The metallic vapour evaporated in the graphite crucible of the furnace was carried with nitrogen gas into the condenser and formed into metallic fume with small-size distribution by self-nucleation. Particle size of generated fume could be easily varied by changing flow rate of the carrier gas and temperature of the furnace. The exposure chamber was a vertical transparent polyvinylchloride cylinder with six cylindrical tubes on the wall into which rats could be inserted and fixed. A metal grid covered one end of each cylindrical tube where the head of each rat inserted into the tube, was placed, so that only the head of each rat in the exposure chamber was exposed to metallic fume.<BR>The inhalation experiments using lead fumes were carried out in order to compare the characters of the new inhalation apparatus with the usual system in which several rats were exposed to the fume together in one cage. As results, higher lung retention rates (about 1.30 times at the aerodynamic median diameter of 0.23μm and 1.54 times at 1.7μm) and smaller variations in weights of inhaled lead fume in each rat lung were observed in the new fixed form inhalation system as compared with the usual free form inhalation system.

• 日本衛生学会の論文

著者

• 本間 克典

  労働衛生研究所

関連論文

• 金属ヒュームの肺内沈着に関する研究 : 第3報 多分散不整形ヒュームのラット肺内への沈着率
• 金属ヒュームの肺内沈着に関する研究 : 第2報 単分散球形金属ヒュームのラット肺内への沈着率
• 金属ヒュームの肺内沈着に関する研究 : 第1報 ラット用金属ヒューム吸入実験装置

スポンサーリンク