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Circadian rhythmicity and some other characteristics of the function of the reticuloendotherial system (RES) were investigated in rats. Male Wistar rats were acclimatized in climatic chambers, which were kept at 25°C and 60% R. H., the light and dark periods, 12 hours each, being reversed. Special attention was payed to the matching of age and body weight of rats. Animals were fed on food pellets and water ad libitum.Determinations of RES function were made mainly by the Congo Red method, but the carbon particle clealance method was also used in some of the experiments.(1) It was found that the RES function of rats showed a ciradian rhythm similar to a sine curve, with its peak in the middle of the dark period and its trough in the middle of the light period.(2) The RES function of the older rats was lower than that of the younger; the difference between light and dark period, however, still persisted.(3) When rats were fasted for 24 hours, an increase in the RES function in the dark period did not take place, the level of the function being similar to that of the light period of both 24 hours fasted and normally fed rats. This suggests that feeding is one of the important factors influencing the circadian rhythm of RES function.(4) With carbon clealance, which proceeds faster than Congo Red clealance, the differance of RES function between light and dark periods was almost imperceptible.(5) Also differances due to lighting conditions were not observed in the clealance of Indocyanin Green, which was chiefly engulfed by hepatic cells.(6) My technique of restraining an animal, which was used throughout these experiments, proved to be suitable for repeated collection of venous blood at fixed intervals.
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