95Zr-95Nbの生体におよぼす影響に関する実験的研究 (1) : ラット皮下投与時の体内分布とオートラジオグラフ
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As previously reported 95Zr-95Nb were detected in fallout and vegetation in consequence of the nuclei explosion.On a point of view for biological effect of 95Zr-95Nb to animal, these radioactive materials were quantitatively injected subcutaneously to rats. These rats were sacrificed respectively at 5 hours, 24 hours, 7 days, 14 days, 28 days and 63 days after the administration. After that, the distribution of 95Zr-95Nb for main organs and tissues were determined and also radioactivities of them in the urine and in the feces were persuited for a long period after injection. Autoradiography of tibia for the victims were taken with a macro-contact method in order to observe locality and turnover for 95Zr-95Nb in the tibia.The results obtained were as follows;1. In the period of the experiments, the radioactivities for 95Zr-95Nb were extremely detected in the tibia rather than in the other organs and tissues. The next highly deposited tissue of them was an upper incisor. But radioactivities of them in main organs except tibia were approximately same level at the 63th experimental day through biological turnover and excretion.2. Amounts of 95Zr-95Nb in both urine and feces among experimental rats were the most mainly excreted in them within 24 hours after injection. After that, these amounts of 95Zr-95Nb excreted in urine and feces per 24 hours gradually decreased day by day and had been kept on at about same level from the 14th experimental day to the end of the experiments. Amount of the substances mentioned above was generally larger in urine than in feces through the experimental period.3. It could be considered from the result of autoradiographic study for the tibia in the experiments that; firstly, 95Zr-95Nb were remarkably deposited into a part of metaphysis close to epiphysis line in the initial stage, the 5th experimental day, and were consequently accumulated into metaphysis rather than into both epiphysis and diaphysis. Secondly, at the 14th experimental day, they released from the metaphysis close to epiphyseal line but their depositions at the part of epiphysis did not so remove.Thirdly, at the 63th experimental day, they had still deposited into the epiphysis.
- 日本衛生学会の論文
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