マウスの免疫応答に及ぼす環境温熱条件の影響

概要

論文の詳細を見る
This article is a summarized report and discussion of a series of experiments carried out to elucidate the many-faceted effects of ambient thermal conditions on change in splenic plaque forming cells (PFC) and humoral antibodies which were chosen as examples of physiological functions. As the results, the following findings were obtained. (1) The effect of thermal environment is more intense just after a change of thermal condition than after acclimation. (2) The adverse effects of high or low ambient temperature do not appear symmetrically as the thermal conditions go up or down from the optimal range. (3) When animals are exposed repeatedly for short period of time to a temperature which would normally exert a suppressive effect on immune response, the results turned out to be stimulative of immune response. (4) In the case of a temperature shift from a moderate to a cold environment, the effect on PFC took place mainly when the shift occurred after immune stimulation, while in the case of temperature shift from a moderate to a hot environment, the effect appeared when the shift took place before immune stimulation and the duration of effect lasted longer. To explain these results an “effective period” in the course of physiological adaptation to the change in ambient temperature and a “susceptible period” in the course of immune response were postulated.This series of experiments revealed that the effects of ambient temperature on the immune response were not simple but rather multilateral and complicated. Although the thermal environment rarely acts as the specific cause of a disease, more detailed knowledge on the influence of thermal environment will render prevention, diagnosis and treatment of diseases more precise and reliable.

著者

菊池正一
順天堂大学

マウスの免疫応答に及ぼす環境温熱条件の影響

スポンサーリンク

概要

著者

関連論文

スポンサーリンク