麻疹ワクチン接種による臨床反応の解析的研究

概要

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A Mass measles vaccination program by the KL method was conducted in Chiba prefecture during two separate priods; from January to March in 1967 to March in 1968.Concerning the clinical reactions during 2 weeks after immunization with live vaccine, observations of 812 vaccinees were done by their mothers, in three areas of Chiba prefecture.Results of mothers, observations were to be objective.The incidence of febrile reaction (more than 37.5°C) was 10.3±4.0%, that of rash 8.9±3.8%, and that of vaccinees manifestation of any clinical signs was 50.8±10.4%.For the analysis of the distribution of the onset day of febrile reaction and rash, data of Chiba city was used. There, 517 vaccinees out of about twenty thousand were observed throughout two weeks and febrile reaction was recorded in 71 cases and rash in 54 cases.According to the analysis of the result by Weibull theory, their manifestations are randomly distributed in the time course. It might be suggested that the factors which randomize the multiplication rate of vaccine virus in the host or which are randomly distributed among vaccinees, play an important role in the manifestation of clinical reactions. Further investigation, however, is required to confirm these findings.
日本衛生学会の論文