95Zr-95Nbの生体におよぼす影響に関する実験的研究 (3) : ラット気管内投与時の体内分布と肺臓のオートラジオグラフィ

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Distribution and excretion of 95Zr-95Nb, which was administrated subcutaneously and orally in rats, had been studied from time to time, for the same experimental period as previous reports. At this time, 95Zr-95Nb were administered to rats of the Wister strain, by intra-tracheal intubation and time trends of distribution in organs as well as excretion in urine and feces of these experimental animals were observed. In addition an autoradiography of lung was performed using the dipping technique in order to observe a finer distribution of 95Zr-95Nb in lung when administered by inrta-tracheal intubation. The results are as follows.1) When 95Zr-95Nb were intubated into the lung, a great amount was retained in and deposited into lung 24 hours after administration and the amount of them decreased considerably after the 7th experimental day. But, it was observed that the amount of 95Zr-95Nb at any time during the experimental period of lung was greater than that for other organs. 63 days after administration, deposition ratio of 95Zr-95Nb for lung held the some level as that of bone which would be considered to be the highest affinity for 95Zr-95Nb among organs.2) The amount of 95Zr-95Nb of tibia increased considerably for 7 days from administration and then began to decrease toward the final experimental day. The rate of decreasing radioactivity in the tibia was considerably slow after the 14th experimental day and the deposition ratio of tibia was the highest among organs excluding the lungs. Therefore, when 95Zr-95Nb was administered into the body, it was considered that bony tissue had strongest affinity of all organs.3) After administrating 95Zr-95Nb, the largest amount was excreted in urine and especially in the feces the first 24 hours through the experimental period. And, 49.86% of 95Zr-95Nb intubated into the lung was excreted in feces until the 63th experimental day and half of the amount of them was contains in the feces excreted until 24 hours after administration. After that, the amount of 95Zr-95Nb excreted in feces suddenly decreased and difference of the amount between feces and urine gradually became less and less toward the final experimental day.4) A micro-autoradiography of the lung at the 63th experimental day revealed the fact there were still a number of blackening spot caused by 95Zr-95Nb in the alveolar wall and some spots were also likely to be in cells in the wall.
日本衛生学会の論文

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森重敏子
九州大学医学部衛生学教室

95Zr-95Nbの生体におよぼす影響に関する実験的研究 (3) : ラット気管内投与時の体内分布と肺臓のオートラジオグラフィ

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