Atherosclerosis Amelioration by Moderate Alcohol Consumption Is Associated With Increased Circulating Levels of Stromal Cell-Derived Factor-1
スポンサーリンク
概要
- 論文の詳細を見る
Background: A moderate intake of alcohol is associated with lower cardiovascular mortality, and the role of circulating progenitor cells in the beneficial effect of alcohol on atherosclerosis is unclear. The hypothesis of this study was that alcohol ameliorates atherosclerosis by modulating the circulating levels of stromal cell-derived growth factor (SDF)-1 and vascular progenitor cells. Methods and Results: Atherosclerosis was induced by infusion of angiotensin II in apolipoprotein-E deficient mice, which were treated with high and low doses of ethanol for 28 days by intraperitoneal injection. Mice treated with low-dose ethanol had significantly less dilatation and fewer atheromatous lesions than mice receiving the high-dose ethanol. The number of circulating fibrocytes was significantly lower in mice treated with high-dose ethanol compared with mice with atherosclerosis untreated with ethanol. The plasma CXCL12/SDF-1 level was significantly increased in mice treated with low-dose ethanol compared with mice treated with a high dose, and the plasma concentration of transforming growth factor-β1 was significantly increased in mice treated with high-dose ethanol compared with control mice. Ethanol regulated the secretion of SDF-1 and vascular endothelial growth factor from fibroblasts in a dose-dependent and bimodal fashion. Conclusions: The circulating level of CXCL12/SDF-1 may be involved, at least in part, in the differential effects of alcohol consumption on atherosclerosis. (Circ J 2011; 75: 2269-2279)
論文 | ランダム
- ネットワーク固有モード伝送の実現に関する一検討(ポスター,一般,ポスター講演)
- A Revision of Japanese Sciomyzidae (Diptera), with Descriptions of Three New Species
- 赤星病抵抗性バ-レ-種B107の育成経過とその特性
- 恫喝されたMSA会談
- 英国「成人教育・訓練」概念の検討--M.Tightの研究をもとに