Effect of Atorvastatin vs. Rosuvastatin on Cardiac Sympathetic Nerve Activity in Non-Diabetic Patients With Dilated Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Background: Effects of statin therapy on cardiac sympathetic nerve activity in patients with chronic heart failure (CHF) have not previously been evaluated. Methods and Results: To compare the effects of lipophilic atorvastatin and hydrophilic rosuvastatin on cardiac sympathetic nerve activity in CHF patients with dilated cardiomyopathy (DCM), 63 stable outpatients with DCM, who were already receiving standard therapy for CHF, were randomized to atorvastatin (n=32) or rosuvastatin (n=31). We evaluated cardiac sympathetic nerve activity by cardiac 123I-metaiodobenzylguanidine (MIBG) scintigraphy, hemodynamic parameters and neurohumoral factors before and after 6 months of treatment. There were no differences in the baseline characteristics of the 2 groups. In the rosuvastatin group, there were no changes in MIBG parameters, left ventricular ejection fraction or plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) after 6 months of treatment. In contrast, the atorvastatin group showed a significant increase in the delayed heart/mediastinum count ratio (2.18±0.4 vs. 2.36±0.4, P<0.0001), and the washout rate was significantly decreased (34.8±5.7 vs. 32.6±6.3%, P=0.0001) after 6 months of treatment compared with the baseline values. The plasma NT-proBNP level was also significantly decreased (729±858 vs. 558±747pg/ml, P=0.0139). Conclusions: Lipophilic atorvastatin but not hydrophilic rosuvastatin improves cardiac sympathetic nerve activity in CHF patients with DCM. (Circ J 2011; 75: 2160-2166)
論文 | ランダム
- 国内初の「児童脳死移植」は疑問だらけだ--情報開示もされず死因究明はおざなりでよいのか
- 高速鋳造時の鋳型内におけるモ-ルドパウダ-の滓化挙動,潤滑挙動と抜熱挙動 (製鋼)
- すべての青少年のスポ-ツ活動・遊びの保障をめざして--日教組/スポ-ツと遊び問題検討委員会中間報告-4-
- はじめに--教科書研究の視点 (教科書研究-10-保健・体育(特集))
- 保健・体育分科会 共通した軍国主義化への危機感 (第18次教研全国集会の成果にまなぶ(特集))