Effects of Quinidine on the Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Patients With Brugada Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Background: On a cellular level, Brugada syndrome has been attributed to a deep phase 1 notch and subsequent shallow and prolonged repolarization in the right ventricular outflow tract (RVOT). A sodium channel mutation that leads to early inactivation of the late sodium current has been identified in some patients. Thus, drugs that inhibit the transient outward current (Ito) responsible for the phase 1 notch and/or enhance the late sodium current might suppress arrhythmic events in patients with Brugada syndrome. The effects of quinidine gluconate, a potent inhibitor of Ito, on RVOT action potential duration (APD) restitution kinetics in patients with Brugada syndrome were evaluated. Methods and Results: Programmed ventricular stimulation was performed in 9 Brugada syndrome patients by delivering up to 3 extrastimuli from the right ventricular apex and RVOT. RVOT monophasic action potentials (MAPs) were recorded before and after intravenous administration of quinidine (n=6) or ibutilide (n=3). All patients had inducible ventricular fibrillation (VF) before drug administration. Both quinidine and ibutilide increased steady-state and minimum RVOT MAP duration during programmed stimulation. Quinidine decreased the maximum slope of the RVOT APD restitution curve and VF could not be induced after administration of quinidine in 5 of the 6 patients. Conclusions: Quinidine appears to suppress the induction of VF by increasing RVOT MAP duration and decreasing the maximum slope of the restitution curve. (Circ J 2011; 75: 2080-2086)
論文 | ランダム
- 経済学の再構築をめざして--ソシオ・エコノミックスの視点と問題点 (経済学は現代を救えるか--「国富論」200年-経済学の系譜と課題)
- 「三極構造」と日本外交--カギ握る中国関係正常化 (保守支配はなぜつづくか(特集))
- 細胞融合による優良ワイン酵母の育種性(図解・微生物の育種)
- 期待と不安の交錯する英国--大欧州への布石になるか (「拡大欧州」の視点(特集))
- 552 酵素法によるワイン中のマスト臭除去に関する研究(第2報) : α-アセトラクテート デカルボキシラーゼのワイン製造への利用