Effects of Quinidine on the Action Potential Duration Restitution Property in the Right Ventricular Outflow Tract in Patients With Brugada Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Background: On a cellular level, Brugada syndrome has been attributed to a deep phase 1 notch and subsequent shallow and prolonged repolarization in the right ventricular outflow tract (RVOT). A sodium channel mutation that leads to early inactivation of the late sodium current has been identified in some patients. Thus, drugs that inhibit the transient outward current (Ito) responsible for the phase 1 notch and/or enhance the late sodium current might suppress arrhythmic events in patients with Brugada syndrome. The effects of quinidine gluconate, a potent inhibitor of Ito, on RVOT action potential duration (APD) restitution kinetics in patients with Brugada syndrome were evaluated. Methods and Results: Programmed ventricular stimulation was performed in 9 Brugada syndrome patients by delivering up to 3 extrastimuli from the right ventricular apex and RVOT. RVOT monophasic action potentials (MAPs) were recorded before and after intravenous administration of quinidine (n=6) or ibutilide (n=3). All patients had inducible ventricular fibrillation (VF) before drug administration. Both quinidine and ibutilide increased steady-state and minimum RVOT MAP duration during programmed stimulation. Quinidine decreased the maximum slope of the RVOT APD restitution curve and VF could not be induced after administration of quinidine in 5 of the 6 patients. Conclusions: Quinidine appears to suppress the induction of VF by increasing RVOT MAP duration and decreasing the maximum slope of the restitution curve. (Circ J 2011; 75: 2080-2086)
論文 | ランダム
- 23564 補強コンクリートブロック壁の力学的性状に関する実験的研究 : (その3) 実験結果の検討
- 306 沖縄の補強コンクリートブロック塀の耐震安全性に関する研究 : その4.那覇市近郊の実態調査(構造)
- (193) カーバム(NCS)の新処理法とタバコ立枯病防除効果 (昭和63年度日本植物病理学会大会講演要旨)
- (22) 人工気象下におけるタバコ野火病菌の罹病植物からの飛散 (昭和60年度地域部会講演要旨(関西部会))
- 土壌消毒によるタバコ野火病および角斑病の発生防止効果