Additive Effects of β-Blockers on Renin-Angiotensin System Inhibitors for Patients After Acute Myocardial Infarction Treated With Primary Coronary Revascularization
スポンサーリンク
概要
- 論文の詳細を見る
Background: Although some β-blockers are effective for patients after acute myocardial infarction (AMI), few studies have compared their additive effects on renin-angiotensin system inhibitors (RAS-Is). Methods and Results: The 251 consecutive AMI patients administered angiotensin-converting-enzyme inhibitors (ACE-Is) or angiotensin-II receptor blockers (ARBs) were retrospectively investigated and divided into 2 groups: treated without β-blockers (no-β-blocker group, n=80) or treated with β-blockers before discharge (β-blocker group, n=171; carvedilol [n=91] or bisoprolol [n=80]). The doses of RAS-Is used for patients in the no-β-blocker group were at least double those used in the β-blocker group. No significant differences between the 2 groups were observed with regard to baseline characteristics. After a 12-month follow-up, the survival and cardiac event-free rates in the β-blocker group were significantly higher than those in the no-β-blocker group. The percent change in blood pressure did not significantly differ between the 2 groups, but the levels of brain natriuretic peptide, metalloproteinase-2, and metalloproteinase-9 and the left ventricular ejection fraction improved significantly in the β-blocker group compared with the no-β-blocker group. Regarding the 2 β-blockers, carvedilol treatment produced more favorable outcomes than bisoprolol. Conclusions: The data suggest that treatment with RAS-I in combination with β-blocker is more effective for patients after AMI than treatment with RAS-I alone. (Circ J 2011; 75: 1982-1991)
論文 | ランダム
- 文庫・BUNKOの今明日(第9回)文庫へのアンケート調査(その2)発送から回収まで
- 夢を追う人たち(20)大谷由里子 イベント企画会社経営
- 中華歎異抄(17)豊饒の中の貧困--固定化する格差構造
- 中華歎異抄(16)「公民社会」と「独立候補」
- Physiological and Biochemical Characterization of Metal-Phytosiderophore Transport in Graminaceous Species