A Counteraction of Cortisol on Lactation Depressing Effect of Estradiol in the Mouse
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Effects of cortisol and prolactin on the lactation depressive action of estrogen were studied in mice. The daily s. c. injections of 1 erg and 10μg estradiol benzoate (EB) from day 3 of lactation decreased the litter weight gain and caused a regression of mammary glands, pronouncedly with a higher dose and with longer treatments. All young in each litter died between day 6 and 9 of injection in a group receiving 10μg. The twice daily s. c. injections of 0.1mg cortisol acetate significantly reduced such suppressive effects of EB upon lactation. All litters continued to gain weight and could survive throughout the entire period of the treatment (10 days) in cortisol injected groups. But, twice daily s. c. injections of 2.5 I. U. of prolactin could not reduce the depressive effect of EB upon lactation. In Experiment 2, each mouse was isografted with 2 anterior pituitaries (APs) under the kidney capsule on day 2 of lactation and received daily s.c. injections of 1μg and 10μg EB from day 3. The inhibitory effect of EB on litter weight gain appeared to a lesser degree in AP grafted groups than in intact groups in the first experiment. In Experiment 3, each mouse was implanted with a cortisol pellet on one side and a cholesterol pellet on the contralateral side of the inguinal mammary glands on day 2 of lactation and received daily s.c. injections of 10μg EB from the next day. Histological inspection showed that there remained functional alveoli filled with milk only at the cortisol pellet implanted site 10 days after implantation. These results suggest that glucocorticoids may be intimately concerned in the mechanism of lactation inhibitory action by estrogen and counteract, at least in part, directly at the site of mammary tissues, although it is not the only hormone involved in this process.
- 一般社団法人 日本内分泌学会の論文