Human Pituitary Corticotrophs: Their Amphophilic Stainability and Immunohistochemical Characterization

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概要

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• Immunohistochemical characterization of the human pituitary β(R) cells was investigated through the findings of the immunoreactivities with anti-porcine ACTH, -rat TSH, -rat LHβ and -rat FSH sera. Immunostained corticotrophs are oval or round in shape and localized in the anteromedial wedge. It is shown on the adjacent sections that they correspond to the β(R) cells with amphophilic stainability with PAS-iron hematoxylin. In this wedge, amphophilic cells are preponderant, but PASpositive thyrotrophs and gonadotrophs are not numerous. Amphophilic stainability varies in degree from cell to cell: One cell contains numerous medium-size of secretory granules weakly stained with iron hematoxylin and strongly with PAS in the PAS-positive cytoplasm, and the other cell is filled with big secretory granules intensively stained with iron hematoxylin and weakly with PAS. The immunostained TSH, LH and FSH cells are different from the β(R) corticotrophs, because anti ACTH serum never reacts to the TSH, LH and FSH cells in the two adjacent sections. LH and FSH reactivities are observed in the single cells. It is concluded that human corticotrophs are amphophilic β(R) cells filled with secretory granules, and that they have quite a different appearance from the rat chromphobic stellate corticotrophs with a row arrangement of secretory granules along the plasma membrane.

• 社団法人 日本内分泌学会の論文

著者

• KUMAGAI TSUNEAKI

  Department of Anatomy, Jikei University School of Medicine

関連論文

• Secretory Cycle of the Pituitary Basophils and Its Morphological Evidence
• Possible Sequential Transformation of a Series of Acidophils in the Pituitary Autografts in the Renal Capsule of Male Rats in Association with ACTH Cell
• Human Pituitary Corticotrophs: Their Amphophilic Stainability and Immunohistochemical Characterization

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