Reversal by a Dopamine Antagonist of Saline-Induced Attenuation of Aldosterone Response to Angiotensin II Infusion in Man

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概要

• 論文の詳細を見る

• In an attempt to elucidate the dopaminergic involvement in the regulation of the effect of angiotensin II on the adrenals, plasma aldosterone response to angiotension II infusion (5ng/kg/min, for 60 minutes) was studied in five normal volunteers in various experimental conditions.<BR>Prior infusion of dopamine (3μg/kg/min) or saline (1000ml/hour) caused an attenuation of the aldosterone response to angiotension II. Concurrent infusion of a dopaminergic antagonist, metoclopramide (10μg/kg/min), abolished the inhibitory effect of doamine and saline.<BR>These results suggest that the dopaminergic mechanism is involved in the adaptive aldosterone response of the adrenal to acute saline loading in man.

• 社団法人 日本内分泌学会の論文

著者

• KOJIMA ITARU

  The 4th Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• OGATA ETSURO

  The 4th Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• Reversal by a Dopamine Antagonist of Saline-Induced Attenuation of Aldosterone Response to Angiotensin II Infusion in Man

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