STUDIES OF COLD TOLERANCE
スポンサーリンク
概要
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Mature mice, acclimatized in a low ambient temperature at -5±1°C, were exposed to the extreme cold at -30--35°C and the survival time was determined. The mice were treated with various preparations during acclimatization or immediately before the exposure.<BR>The results obtained are as follows: 1) The time required for acquisition and disappearance of acclimatization to cold was less than 1 week. 2) Prednisolone increased the survival time of mice when treated before exposure, while it decreased the cold tolerance probably due to adrenal suppression when treated during acclimatization. 3) DOCA was without effect. 4) Thyroxine increased the survival time regardless of the time of medication, whereas methylmercaptoimidazole decreased it when treated during acclimatization. 5) Chloropromazine increased the cold tolerance directly, while reserpin was without effect. 6) Castration appeared to increase the cold tolerance. 7) The survival time of the male mice was longer than the female. 8) Androgen was without effect, while estrogen increased the cold tolerance when treated during acclimatization of the castrated mice of both sexes.
- 社団法人 日本内分泌学会の論文