加熱滅菌時におけるブドウ糖注射液の変化について

概要

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Estimation of pH of commercial glucose injections by use of glass electrode showed to be pH 3.54.3. These lower pH values are attributed to the decomposition of glucose by heating to 5-(hydroxymethyl)-2-furaldehyde, its further decomposition gives an equimolar mixture of formic acid and levulinic acid and glucose injections buffer action are very slight and cause much error when estimated by pH indicating papers. The concentration of formic acid and levulinic acid, respectively, is 5 × 10-5 to 5 × 10-4 N. The acidiy can be estimated by high frequency titration or it can be estimated by making a graph from relations of concentration of acid and pH values. Although these lower pH values are considered to be harmless for injection due to its weak buffer action, it is rather striking to note such lower pH values and a sugestion for revision of Pharmacopoeia Japonica VI is made, since it specifies to be pH 5. 07. 0
社団法人日本分析化学会の論文