交流ポーラログラフィーによる点眼剤中のチメロサールの定量

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Thimerosal (sodium ethylmercurithiosalicylate), commonly used as an antiseptic and a preservative, showed a well-defined a. c. polarographic wave in 0.1M sodium perchlorate supporting electrolyte solution. Thimerosal produced two a. c. polarographic peaks, the summit potentials of which were ca. +0.07V and ca.-0.73V vs. Hg pool respectively. A. c. wave of thimerosal seemed to have both faradaic and non-faradaic nature, and the substances, such as chlorpheniramine maleate and dibucaine hydrochloride, which are absorbed at the dropping mercury electrode stronger than thimerosal, decrease the peak height of thimerosal (Table II, Fig. 6). A sensitive and selective a. c. polarographic method for the determination of 0.00020.003 w/v% of thimerosal in commercially available eye lotions is described. The determination is carried out without prior separation of thimerosal and is based on standard addition method measuring the peak height at ca. -0.73V vs. Hg pool (the second peak) on the a. c. polarogram recorded with sample in 0.1M sodium perchlorate supporting electrolyte solution at pH 9. Results, reproducible to within 1.57% coefficient of variation, were obtained on an eye lotion sample containing 0.002 w/v% of thimerosal (Table IV).
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