細胞間情報伝達シグナルとしての張力
スポンサーリンク
概要
- 論文の詳細を見る
The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, contractile function and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as a site where signal transduction from cadherin ligation takes place through cell adhesion as seen with other conventional membrane receptors. Recent studies are unraveling the existence of mechanotransduction at AJs and its possible molecular mechanism in which α-catenin in the cadherin-catenin complex changes its conformation in a force-dependent manner. This mechanotransduction has advantages in that it can transmit more precise temporal, quantitative, and spatial information than signaling using diffusion of second messengers or phosphorylation cascades.
論文 | ランダム
- 超元気な企業誕生の秘密 (「オンリ-ワン企業」が日本を救う)
- 20世紀の証言 「恐慌の責任誰が」角さん激怒「山一・日銀特融」の仕掛け人 岩佐凱実
- 実力派外資系のドライな素顔 (ビッグバン突入)
- 金融離れ/手続きはインタ-ネット--就職戦線新事情--ブランドよりやりたい仕事 (雇用革命の時代)
- ヘムタンパク質の高機能向上・改変--有機合成を駆使したタンパク質工学