Two Calcium-Binding Proteins, MRP8 and MRP14: A Protein Complex Associated with Neutrophil and Monocyte Activation.
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概要
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Migration inhibitory factor-related proteins-8 (MRP8) and MRP14 comprise a heterodimeric molecule. This complex molecule consisting of 8kDa and 14kDa subunits (MRP8/14 complex) contains two chracteristic Ca2+-binding regions named EF hands in each subunit. The MRP8/14 complex is expressed mainly in peripheral blood neutrophils and monocytes but not in resting tissue macrophages. It is also induced in human cultured leukemia cells including HL-60 promyelocytic leukemia cells by treatment with differentiation-inducing agents. The MRP8/14 complex also appears in human sera. Its serum level is high in patients with cystic fibrosis, rheumatoid arthritis, sarcoidosis, and other chronic diseases. To date, several groups of investigators have demonstrated this complex's modulation of cellular kinase reactions, its configurational changes in a Ca2+-dependent manner, and its transition from the cytosol to the membrane during neutrophil activation. Such observations may be an important clue to understanding the functional role of MRP8 and MRP14.
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