Antioxidant and Hepatoprotective Actions of the Medicinal Herb Artemisia campestris from the Okinawa Islands
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The antioxidant action of Artemisia camprestris was examined in vitro and in vivo. A water extract of A. campestris showed a strong scavenging action of 1, 1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals. When the extract was given intraperitoneally to mice prior to carbon tetrachloride (CCl<SUB>4</SUB>) treatment, CCl<SUB>4</SUB>-induced liver toxicity, as seen by an elevation of serum aspartate aminotransferase and alanine aminotransferase activities, was significantly reduced. Depression of the elevation of serum enzyme levels after CCl<SUB>4</SUB>-treatment was also observed by oral administration of the extract. In that case, CCl<SUB>4</SUB>-derived lipid peroxidation in the liver was decreased by the extrac treatment. These results suggest that the extract of A. comprestris scavenges radicals formed by CCl<SUB>4</SUB> treatment resulting in protection against CCl<SUB>4</SUB>-induced liver toxicity.
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