ホスト-ゲスト錯体形成による光学分割

概要

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Alkaloids such as brucine and sparteine were shown to be useful for optical resolution of tertiary acetylenic alcohols, cyanohydrins, and secondary alcohols by a host-guest complex formation. Some chiral host compounds which are useful for optical resolution were designed by a simple idea, and the application of these to the resolution of a wide variety of organic guest compounds was reported. In some cases of the optical resolution of guest compound by alkaloids or synthetic host compounds, racemic guest compound was converted into one optical isomer through a combination of its racemization and the complexation. In some cases, racemic host compounds were resolved by a complexation with optically active guest compound. It was also reported that achiral amines such as DABCO, N, N-dialkylpiperazine, and pyrazine are useful for optical resolution of a partially resolved alcohols by a complex formation of them. It was also shorly reported that optically active host compound can be used for an enantioselective reaction of the guest compound included in it.
社団法人有機合成化学協会の論文