マイケル付加反応を利用する隣接三級不斉炭素の立体制御

概要

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The stereocontrolled construction of the adjacent tertiary carbons is important in the synthesis of various natural products. By conducting the Michael addition of ester and amide enolates to α, β-unsaturated esters under appropriate reaction conditions, glutaric acid derivatives with definite relative and absolute configuration are prepared. In combination with intramolecular carbon-carbon bond formation, the process is extended to the stereoselective formation of extracyclic chiral centers, and successfully applied to the synthesis of (+) -dehydroiridodiol. Several other approaches to the stereoselective synthesis of adjacent tertiary carbons are also included.
社団法人有機合成化学協会の論文