2,3,5,6-テトラクロルトルエンの合成(第2報) : 硫酸溶媒を用いたP-トルエンスルホン酸の塩素化

概要

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In the light of the results of the preceding study, a further attempt was made to improve the chlori. nation reaction of p-toluenesulfonic acid into 2, 3, 5, 6-tetrachlorotoluene sulfonic acid in sulfuric acid. Sulfuric acid has thus proved to serve as a good reaction medium, and an improved yield (70-80%) was attained in a short reaction time. However, when the reaction temperature was 100-110°C or above, the formation of highly chlorinated by-products such as pentachlorotoluene was accelerated. At lower temperatures such as 50°C, essentially no reaction took place.
社団法人有機合成化学協会の論文