水やアミンを反応剤に用いる位置および立体選択的反応

概要

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Utilization of water as a reagent as well as a solvent is an important topic in synthetic organic chemistry. This article describes recent progress of hydration and hydrolysis reactions catalyzed by transition metal complexes. Direct transformation of 1-alkynes into aldehydes by Ru (II) -catalyzed hydration has been developed. It has been long known as a textbook example that the hydration follows Markovnikovs rule to give ketones as a sole product. Mechanistic study of the transformation revealed that Ru (II) -vinylidene complexes presumably are not involved in the current hydration reaction, but Ru (IV) -hydride-vinylidene complexes are concerned. Ru (II) -catalyzed hydroamination and its application to heterocycle synthesis are also described. This paper also illustrates metal catalyzed hydrolysis of terminal epoxides, alkenyl esters and ethers. Hydrolytic kinetic resolution of some chiral terminal epoxides and vinyl ethers are also developed.
社団法人　有機合成化学協会 (The Society of Synthetic Organic Chemistry, Japan)の論文