合成プロセスを最適化する触媒開発の探求

概要

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Catalyst developments so as to improve synthetic process are described. Efforts focused in this article include: Design of a catalyst which gives higher catalytic activities and enantioselectivities, development of a new reaction that can bypass a conventional synthetic route, and creation of new catalytic reaction that can replace stoichiometric reactions. These efforts contribute to reduction of cost, waste, and production time. Exemplified herein are: (1)SEGPHOS® ligands that enhanced catalytic activity and selectivity, (2)direct reductive amination that enabled short-cut process en route to β-amino acids from the β-ketoesters, (3)catalytic ester reduction with hydrogen gas that circumvents the use of stoichiometric amounts of metal hydrides, and (4)a Zn cluster catalyst that mediates catalytic acylation and deacylation.