多置換オレフィン類の立体選択的構築

概要

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Stereoselective synthesis of tri- and tetra-substituted olefins is reviewed based on original papers published mostly in the last two decades, during which a great progress has been made in methodology and selectivity. The methodology for the synthesis can be classified into the following five categories : 1) conversion of acetylenes into polysubstituted olefins, 2) reactions of alkenes with organo-transition metal species, 3) reactions involving carbonyl compounds, 4) elimination reactions, and 5) rearrangement reactions. Each category is devided, when needed, into several subclasses. In reviewing stereoselective methods, basic methodology and concept for achieving high selectivity are emphasized, and the application of these methods is only briefly illustrated. The most remarkable feature of the recent progress is establishment of highly stereocontrolled syntheses of isomeric pairs of olefins using common starting materials or intermediates.
社団法人有機合成化学協会の論文