フリーデル・クラフツ反応

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概要

• 論文の詳細を見る

• Friedel-Crafts reactions are the electorophilic reactions catalyzed by Lewis acid type acidic halides or proton acids. They require a reactant-catalyst complex which can interact with either π-or δ-donor type subutrates.The electrophilic complex is either polarized or ionic type. There is no difference in principle between reactions of π- and δ-donor systems, but the π-bonds generally react more readily. Reaction of the electorophilic complex with the substrate results in the formation of an intermediate δ-complex, which determines the reaction rate. Electrophilic aromatic substitutions involving strongly electrophilic reagents show low substrate selectivity, but high positional selectivity. This suggests that the transition state lies early on the reaction coordinate, resembling π-complex. In reactions with weak electrophiles, it lies late, resembling intermediate δ-complex.

著者

• 中根 良平

  理化学研究所

関連論文

• フリーデル・クラフツ反応
• 同位体の分離
• Friedel-Crafts反応の反応機構
• On the Measurements of Separation Factor for Boron Isotope Exchange
• Measurements of Isotope Ratio by Mass Spectrometry(III):Measurements of Isotope Abundance Ratjo of Nitrogen

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