核酸合成における保護基

概要

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Protecting groups used in the chemical synthesis of nucleic acids are reviewed in terms of protections for the hydroxyl groups, the heterocyclic amino groups and the phosphate esters. 1. Protection for hydroxyl groups 1.1 Protecting groups for the primary hydroxyl groups 1.2 Protecting groups for the secondary hydroxyl groups 1.2.1 Acyl groups 1.2.2 2-Acetals and ketals 1.2.3 Other protecting group for hydroxyl groups 2. Protection for heterocyclic amino groups 3. Protection for phosphate esters 3.1 Protection for phosphomonoesters 3.2 Protection for phosphodiesters