最近の合成ピレスロイドとその立体異性体の化学と作用
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概要
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Initially, a number of important or established synthetic pyrethroids containing the chrysanthemate moiety are introduced, and there are also described the relative insecticidal potencies of specific stereoisomers of the chrysanthemates resulting from acid stereochemistry. Recently, many studies on structure modification of the acid moiety of pyrethroid have disclosed a number of the most distinguished synthetic pyrethroids containing diversely modified acid moieties, which have been successfully developed as the most outstanding pyrethroid insecticides in the recent years.<BR>Since a majority of the chrysanthemates now have been reinforced on the insecticidal potency basis by the synthetic selection of useful stereoisomers, various relevant methods of synthesis are progressively reviewed on optical resolutions followed by racemizations, a stereoselective synthesis and/ or a synthesis by asymmetric induction of optically active chrysanthemic acids in close reference to the insecticidal activities of resultant stereoisomers. Relevant methods leading to all the fenvalerate stereoisomers and specific stereoisomer mixtures resulting from the chirality of the alcohol moiety are also described.<BR>Finally, some of specific advantages that are delivered by the stereoisomer selection are commented regarding the insecticidal performance aspects essentially linked with developmental potentials of the synthetic pyrethroids.
- 社団法人 有機合成化学協会の論文