非酵素的アミノ基転移反応によるα-アミノ酸の不斉合成

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概要

• 論文の詳細を見る

• A system mimicking vitamin B<SUB>6</SUB>-dependent transaminases capable of enantio-face differentiation has been developed through the synthesis and the utilization of a couple of pyridoxamine analogs with planar chirality. Diverse α-keto acids were transformed into the corresponding α-amino acids with high enantiomeric excesses through the reaction with one of the chiral pyridoxamine analogs in the presence of Zn<SUP>+2</SUP>. The molar ratio of Zn<SUP>+2</SUP> <I>vs</I>. the chiral pyridoxamine analog was an important factor which greatly influenced the enantiomeric excess of the product. The observed strict correlation between the absolute configuration of the pyridoxamine analog used and that of the amino acid produced was well rationalized.

• 社団法人 有機合成化学協会の論文

著者

• 葛原 弘美

  理化学研究所

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