種々の動物の筋肉加水分解物が末梢循環に与える影響

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Peripheral vasodilating activities of peptide fractions of muscle hydrolysates from various animals were observed by following changes in femoral artery blood flow of dog and in the blood flow of the abdominal subcutaneous tissues of rabbit. Sample animals were fur seal, caribou (North American reindeer), dolphin, cat, dog, cattle, horse mackerel, Alaska pollack and squid. The peptide fractions from muscle hydrolysates were prepared by gel chromatography on Sephadex G-25. Fraction 2 in the elution profile of each sample as shown in Fig. 1 was freeze-dried and a faint yellow powder was obtained.A rise in arterial blood flow occurred immediately after the injection of saline solution containing 5 mg of the powder, the highest changes being observed in fur seal, caribou and dolphin in that order. In other mammals, fish and squid, only a feeble increase in blood flow was observed (Fig. 2).With the peptide fractions from fur seal and caribou, an increase of about 15-20% was observed in the blood flow of the abdominal subcutaneous tissues to which an ointment containing 0.07-0.5% of the powder had been applied. Similar treatment using peptide fractions from the other animals produced a decrease in blood flow (Fig. 3).
公益社団法人日本水産学会の論文