ニトロフラン誘導体による細菌脱アミノ反応の阻害に就て
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概要
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Inhibition of dehydrogenation systems involved in carbohydrate metabolism of certain bacterial cells is considered as one of the causes of bacteriostasis provoked by 5-nitro-2-furfuraldehyde semicarbazone (NFS). In connection with metabolism of nitrogenous compound, few information have been made available for the action of nitrofuran derivatives against bacterial dearnination except a fact that NFS has no remarkable effect upon protease, amino-acid decarboxylase, an tryptophanase of bacterial origin. However, as specific dehydrogenase systems are known to participate in some bacterial deamination, we have made an assum ?? tion that NFS might be effective in inhibiting bacterial deamination. With this view in mind we have carried out a series of experiments to ascertain the effects of nitrofuran derivatives, NFS and NFA (5-nitro-2-furylacrylic amide), on the oxydative deamination of glycine, alanine, and glutamic acid in resting cell suspensions of E. col ?? , The results obtained are as follows; 1) In resting cell suspensions of E. col ?? , nitrofuran derivatives (NFS and NFA) and sodium nitrite inhibit oxydative deamination of glycine and alanine. 2) Amoung these compounds, NFA showed inhibition more active than NFS, while sodium nitrite was the least effective of them in inhibition. This sequence of the agents in the inhibition seems to correspond with that of their effects in bacteriostatic action. 3) Furfural semicarbazone, one of the non-nitrated furan derivatives, gives little inhibitory action. 4) From these results, it may be said that the inhibitory action of nitrofuran derivatives and sodium nitrite on the bacterial deamination is connected with the bacteriostatic action of these agent to some extent, and that incidence of the inhibitory action of nitrofuran derivatives depends not only on nitro-group but also on some structural relation of the compounds. 5) Deamination of glycine is more strongly inhibited by the agents than that of alanine.
- 公益社団法人 日本水産学会の論文
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