Trigeminal Nerve and Brainstem Catecholamine Systems in Cerebral Vasospasm

スポンサーリンク

概要

• 論文の詳細を見る

• Cisternal blood injection in the rat and squirrel monkey produces a biphasic cerebral vasospasm, a decrease in cerebral blood flow (CBF) and an increase in glucose uptake (CMRglu) due to an anaerobic glucolysis actually representing a decrease in metabolism. Lesioning of the A2-nucleus, its ascending cathecolamine pathways or their projection site, the median eminence in the hypothalamus, prevents the occurrence of spasm. A unilateral postganglionic trigeminal lesion causes an ipsilateral constric-tion of the cerebral arteries while a preganglionic lesion does not affect the baseline arterial diameter. Both kinds of trigeminal lesions induce a global increase in glucose uptake of about 50% without in-fluencing CBF. Following subarachnoid hemorrhage (SAH) the decrease in CBF in both groups of lesioned animals is similar to that seen in controls. After SAH there is no further change in CMRglu in the animals with a preganglionic lesion, while in the postganglionically lesioned animals there is an ad-ditional increase in CMRglu of about 50% as compared to controls or animals with a preganglionic le-sion. Treatment with the peptidergic substance P (SP) antagonist, spantide, or gammaglobulin against SP prevents or significantly reduces the degree of spasm and the changes in flow and metabolism nor-mally seen post-SAH. The non-peptidergic neurokinins NK1 and NK3 antagonists do not influence flow and metabolism in SAH animals. The NK2 seems to change both flow and metabolism post-SAH in rats.

著者

• SVENDGAARD Niels-Aage

  Department of Neurosurgery, Karolinska Hospital

• GOKSEL Murat

  Department of Neurosurgery, Cumhuriyet University

• WESTRING Sophia

  Department of Neurosurgery, Karolinska Hospital

関連論文

• Trigeminal Nerve and Brainstem Catecholamine Systems in Cerebral Vasospasm

スポンサーリンク