Chromosome changes and in vitro transformation of hamster embryonic lung cells induced by dimethylnitrosamine in combination with an activation system. A preliminary note.:A Preliminary Note
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概要
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this is the first to report that DMN induces cell transformation in vitro in the presence of an activation system. Evidence presented is suggestive of that DMN is activated by the liver microsomal fraction, and then reacts with target DNA causing chromosome changes and finally cell transformation in vitro.
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